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Researcher finds personal reasons for cancer work


February 19. 2013 2:45PM
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ATLANTA - LaTonia Taliaferro Smith is waging a personal war on breast cancer from her Emory University lab.


The disease, which is a leading cause of cancer death in women behind the No. 1 cause of lung cancer, has affected 10 women in her husband's family. Perhaps even more.


She has a 12-year-old daughter who she prays will never have to hear the chilling words You have breast cancer.


It's been devastating, said Smith, a researcher specializing in triple negative breast cancer at the Winship Cancer Institute of Emory University. We celebrate deaths as much as we do birthdays. I've been a sounding board for family members, friends and friends of friends who are newly diagnosed. It's heartbreaking and there's nothing I can do about it — at least for this generation.


Smith's lab is on the front lines of the war against breast cancer, particularly triple negative breast cancer, which disproportionately affects younger women, African-Americans and Hispanics. Each day, she comes to work at the lab intent on finding better treatment options — and perhaps, one day, a cure.


Triple negative is one of several subtypes of breast cancer.


There's no longer a medical model of one size fits all, said Dr. April L. Speed, a breast surgeon and expert on breast cancer.


Triple negative is more challenging to treat than many forms of breast cancer because the tumor lacks the three known receptors that fuel most kinds of the disease, rendering some treatments ineffective.


Smith said triple negative represents about 15 percent to 20 percent of breast cancer cases.


The incidence of triple negative disease in black women with breast cancer ranges from 26 percent to 46 percent; the incidence in non-black women is between 13 percent and 16 percent.


Certainly some of the disparity is due to poorer access to health care, meaning many black women do not seek treatment until the disease has progressed to later stages, said Dr. Ruth O'Regan, a professor and vice chairwoman of educational affairs, hematology and oncology at Emory's School of Medicine. Research, however, has shown a disparity in the subtypes of breast cancers that black women develop compared with white women. Triple negative breast cancers have the worst outcome of all breast cancer subtypes, with a high risk of recurrence within five years of diagnosis. Smith said the outcomes for black women with triple negative breast cancer tend to be worse than those for white women. She thinks the key may be a molecular and environmental basis for these differences. And generally, when there is a recurrence of triple negative disease, the cancer returns much more aggressively.


Smith doesn't know how many of her husband Duane's relatives in New Orleans had triple negative breast cancer. She suspects several did, but she doesn't know for sure because some medical records were lost in the flooding after Hurricane Katrina slammed the city in 2005 or because some cases were too old.




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